نوع مقاله : مقاله پژوهشی
نویسندگان
1 دانشیار مهندسی مکانیک، دانشگاه اراک، اراک، ایران
2 دانشیار، مهندسی ساخت و تولید، دانشکده فنی و مهندسی، دانشگاه اراک، اراک
3 کارشناسی ارشد، مهندسی ساخت و تولید، دانشکده فنی و مهندسی، دانشگاه اراک، اراک
4 گروه مهندسی مکانیک، دانشکده فنی و مهندسی، دانشگاه اراک ، اراک
چکیده
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Today, the atomic force microscope has various applications in the manufacture of small-scale parts and the study of their mechanical properties. The study of mechanical properties of tissues can be considered as biomarkers for early detection of cancer and help in new treatments. There are diferent ways to detect cancerous tissues, and one of these ways is to check Young’s modulus of the tissue. One of the most recent methods for extracting Young's modulus in biological tissues is the use of atomic force microscopy. In this study, atomic force microscope was first used to extract Young's modulus of MCF-10 breast cancer tissue using 3 different cantilevers with rectangular, V-shaped and dagger geometries. The geometry of the cell was also assumed to be spherical according to the images obtained by atomic force microscopy. The force- indentation depth diagram was plotted by averaging the experimental results for each of the cantilevers separately. Finally, Young's modulus of breast cancer tissue for 3 cantilevers with rectangular, V-shaped and dagger geometries is extracted with Hertz contact model. By comparing the experimental and theoretical results and by changing the assumed range of Young's modulus for all 3 geometries of the cantilevers, it was observed that the use of V-shaped pole predicts a more accurate range of Young's modulus due to applying less force to the tissue. Young's modulus of breast cancer was considered between 1200 and 1250 (Pa) using V-shaped cantilevers.
کلیدواژه‌ها [English]
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