عنوان مقاله [English]
Goals such as not harming healthy tissues and other organs when using medicine and identifying cancerous tissues as soon as possible have led to the entry of nanoscience into the field of medicine. In this regard, a research was conducted considering various tools and methods, and the most desirable of these methods was the nanomanipulation method based on the atomic force microscope due to its many applications in the study of cell tissues in different environments. Therefore, in this article, in order to find the optimal amount of force and critical time in nanomanipulation of cancer tissue, with the aim of exploring the surface and obtaining information about gastric cancer tissue with the least damage, 2D simulation of nanomanipulation has been carried out. The important factor investigated in this research is friction, which is one of the factors that resist movement and has a direct effect on force and critical time. Therefore, with the development of simple friction models, considering Carlson-Batista, Lemaitre-Carlson and FKT friction models, force-time diagrams have been drawn and critical force and time values have been calculated. The lowest value of the force was equal to 0.453 nN and the lowest value of the critical time was equal to 45 ms, which was obtained from the simulation with the FKT friction model. Also, by comparing these values with past researches, a decrease in force and critical time compared to the LuGre friction model has been seen.