Journal Of Applied and Computational Sciences in Mechanics

Journal Of Applied and Computational Sciences in Mechanics

Manipulation of breast cell tissue with the aim of calculating Young's modulus, using Tatara contact theory and atomic force microscopy

Document Type : Original Article

Authors
Moein Taheri 1
hamed faraji 2
Peyman Karimi 3
1 Department of Mechanical Engineering, Faculty of Engineering, Arak University, Arak, Iran.
2 Department of Mechanical Engineering, Faculty of Engineering, Arak University, Arak
3 Mechanical Engineering, Faculty of Engineering, Arak University, Arak, Iran.
10.22067/jacsm.2023.80537.1156
Abstract
Atomic force microscopy is a powerful and precise tool for identifying particle properties and studying intermolecular forces, surface topography, and particle manipulation in the micro-nano dimension. Nanomanipulation is one process that makes good use of this tool. Today, with advances in science and technology, manipulation is used to modify and manufacture the properties of materials, produce more valuable medical components and fewer raw materials, alter the structure of living cells and much more. We are working at the nanoscale. Therefore, in this study, we used atomic force microscopy to investigate the mechanical properties of breast cancer tissue during the nanomanipulation process. By considering the changes induced by the displacement force, force curves and penetration depths are plotted over time. Given the importance of nanoparticle-particle contact and the tatara contact model and breast cancer tissue geometry, simulations were performed to extract the Young's modulus. Experimental experiments and experimental charts were also performed to verify the agreement between the results of the simulation process based on atomic force microscopy. Finally, using the comparisons made in this study and considering the tatara contact model, a range of 2–2.5 kPa was calculated for breast cancer tissue volume.
Keywords
Cancerous tissue
contact model
nanomanipulation
atomic force microscopy
Subjects
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