Numerical Simulation of Same-sized Cells Focusing and Separation with Surface Acoustic Waves

Shahani, Donya; Ramiar, Abas; Mahboubidoust, Arash

doi:10.22067/jacsm.2021.56217.0

Numerical Simulation of Same-sized Cells Focusing and Separation with Surface Acoustic Waves

Document Type : Original Article

Authors

Donya shahani ¹

Abas Ramiar ²

Arash Mahboubidoust ¹

¹ Mechanical Engineering, Microfluidics and MEMS Lab, Babol Noshirvani University of Technology.

² Microfluidics and MEMS Lab, Babol Noshirvani University of Technology.

10.22067/jacsm.2021.56217.0

Abstract

Detection and analysis of circulating tumor cells can provide important information to prevent the spread of cancer, which annually kills millions of people worldwide. So the researchers are trying to find a way to separate these cancer cells for detecting them. In this study, the OpenFOAM code was used to simulate the sheathless focusing and separation of White Blood Cells from Prostate cancer cells using standing and traveling surface acoustic waves in two stages. In the first stage, cells are focused in the center of the channel utilizing standing waves. Then, with the aid of traveling waves, the white blood cells are pushed to the opposite side and the two cells are separated by 100% efficiency.

Keywords

Acoustophoresis

Traveling Surface Acoustic Waves

Standing Surface Acoustic Waves

Cell Separation

Numerical Simulation

Microfluidic

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