شبیه‌سازی عددی کارایی دارورسانی مغناطیسی در شریان مغزی بیماران دیابتی بر اساس بازسازی هندسه واقعی از تصاویر CT

نوع مقاله : مقاله پژوهشی

نویسندگان

محمدعلی قلی پور

بهزاد قاسمی

افراسیاب رئیسی

مرتضی بیاره

گروه مهندسی مکانیک، دانشکده فنی و مهندسی، دانشگاه شهرکرد، شهرکرد، ایران.

10.22067/jacsm.2025.94646.1347

چکیده

در این پژوهش، کارایی روش دارورسانی مغناطیسی (MDT) برای بیماران مبتلا به دیابت نوع ۲ با استفاده از شبیه‌سازی عددی بررسی می‌شود. برای این منظور، هندسه واقعی شریان مغزی بر اساس تصاویر CT بازسازی و جریان خون به‌صورت سیال غیرنیوتنی مدل‌سازی می‌گردد. اثر پارامترهای کلیدی مانند ویسکوزیته خون، قطر نانوذرات حامل دارو و شدت میدان مغناطیسی بر درصد جذب ذرات تحلیل می‌شود. نتایج نشان می‌دهند که افزایش قطر نانوذرات از ۲۵۰ به ۱۰۰۰ نانومتر باعث افزایش راندمان جذب از حدود ۳۳% به ۶۱% می‌شود. همچنین افزایش شدت میدان مغناطیسی از 5/0 به ۱ تسلا، راندمان جذب را تا 59% افزایش می‌دهد. بررسی رفتار جریان خون در دو فاز دیاستول و سیستول نیز نشان می‌دهد که سرعت جریان و تنش برشی جداره در فاز سیستول بیشتر بوده و این تغییرات، طراحی بهینه میدان مغناطیسی را ضروری می‌سازد. نتایج این مطالعه تأکید می‌کند که برای بهبود عملکرد MDT در بیماران دیابتی، باید ویژگی‌های غیرنیوتنی خون، اندازه نانوذرات و شدت میدان مغناطیسی به‌طور همزمان و بهینه در طراحی سیستم لحاظ شود.

کلیدواژه‌ها

دارورسانی مغناطیسی

دیابت نوع ۲

شبیه‌سازی عددی

رفتار غیرنیوتنی خون

نانوذرات حامل دارو

میدان مغناطیسی

موضوعات

• سیال با ذرات میکرو و نانو

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عنوان مقاله English

Numerical Simulation of Magnetic Drug Targeting Efficiency in Cerebral Arteries of Diabetic Patients Based on CT Image-Based Geometry Reconstruction

نویسندگان English

Mohammadali Gholipour

Behzad Ghasemi

Afrasiab Raisi

Morteza Bayareh

Department of Mechanical Engineering, Shahrekord University, Shahrekord, Iran

چکیده English

This study assesses the efficiency of magnetic drug targeting (MDT) for patients with type 2 diabetes using numerical simulation. A patient-specific cerebral artery geometry was reconstructed based on CT images, and the blood flow was modeled as a non-Newtonian fluid. Key parameters, including blood viscosity, nanoparticle diameter, and magnetic field intensity, were analyzed for their effects on drug carrier capture efficiency. The results showed that increasing the nanoparticle diameter from 250 nm to 1000 nm enhanced the capture efficiency from about 33% to 61% in the fourth cardiac cycle. Moreover, increasing the magnetic field intensity from 0.5 T to 1 T improved the capture efficiency up to 59%. The analysis of blood flow during diastole and systole demonstrated that higher flow velocity and wall shear stress in systole significantly influence the drag force acting on the nanoparticles. Overall, this study confirms that considering the non-Newtonian behavior of blood, selecting an appropriate nanoparticle size, and optimizing the magnetic field strength are crucial for improving MDT performance in diabetic cancer patients.

کلیدواژه‌ها English

Magnetic Drug Targeting

Type 2 Diabetes

Numerical Simulation

Non-Newtonian Blood

Drug Carrier Nanoparticles

Magnetic Field

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